Traditional PKD is a dominant gene, and since the disease always shows in affected offspring it is fairly simple to track the lineages involved. Pedigree analysis have revealed five potential distinct entry points of PKD in the Siberian breed, though new cases in kittens imported from Russia are still being reported.
1) The majority of reported PKD cases come from the mating of Kuzya and Lemurotchka. Germany currently has the highest concentrations of this line, but it has also been widely dispersed in the U.S. and several other countries. These cases consistently test positive using the Persian PKD DNA test. Roughly half of the offspring from Kuzya have been shown to have PKD.
2) Pyramid Kazan of Croshka and his daughter died very young of PKD, with confirmation by necropsy. Samskatts Texas Star also tested positive, and is from the same ancestry. The focal point for these pedigrees is: Gesha Olenya Krasa - Dolka Olenya Krasa - and Dima El Magrib. This line can be tested using the standard PKD gene test. Revised July 2010.
3) Gregory's Siberian Petra Jamesova and Gregory's Siberian Penelope Jamesova. Associazione del Gatto Siberiano has reported two siblings with PKD. Both cats have had extensive workups, and the diagnosis was confirmed by DNA. Of specific concern however, DNA was also sent to UC Davis where it tested negative. Dr. Lyons confirmed that there are small variations between the tests that could account for this result, but has begun full sequence of the sample in an effort to isolate any potential differences. This line should be tested by ultrasound until this study is concluded.
4) Uliana Golden Assolada (same pedigree as linked here) was diagnosed with PKD by ultrasound, but was not tested by DNA. No additional cases have been reported from this line, but it seems prudent to test kittens of this pedigree.
Two imported siblings in the UK were diagnosed by genetic testing and returned to the breeder in Russia. No additional cases have been reported on that line, but the majority of cases go unreported. Both kittens tested positive for Persian PKD, indicating an outcross with Persian.
